HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isobutyl Ketone → HCID 13105525, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isobutyl Ketone | HCID 7909 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Benzhydrylpiperazine | HCID 70048 | — |
| Reactant | 1-(2-Chloroethyl)-1,3-dihydro-2H-benzimidazol-2-one | HCID 3653471 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13105525 | HCID 13105525 | — |
Reaction Steps
A mixture of 4.5 parts of 1-(2-chloroethyl)-2,3-dihydro-1H-benzimidazol-2-one, 5 parts of 1-(diphenylmethyl)piperazine, 6.4 parts of sodium carbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with water-separator. The reaction mixture is cooled and water is added. The precipitated product is filtered off and crystallized from a mixture of N,N-dimethylformamide and water, yielding 1-{2-[4-(diphenylmethyl)-1-piperazinyl]ethyl}-1,3-dihydro-2H-benzimidazol-2-one; mp. 218° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04200641 |
| Source dataset | uspto-grants-1980_04 |
| ORD ID | ord-cc130f70325946d7926db4c84bd65545 |
| Source note | uspto-grants-1980_04 |