反应详情

A mixture of 10.7 parts of 1-{3-[4-(diphenylmethyl)piperazinyl]propyl}-1H-benzimidazol-2-amine, 5.1 parts of acetic acid anhydride and 90 parts of methylbenzene is stirred and refluxed for 5 hours. The reaction mixture is evaporated and the residue is stirred in water. The whole is alkalized with ammonium hydroxide and the product is extracted with trichloromethane. The extract is dried, filtered and evaporated. The residue is crystallized from ethanol. The product is filtered off and dried, yielding N-[1-{3-[4-(diphenylmethyl)-1-piperazinyl]propyl}-1,3-dihydro-2H-benzimidazol-2-ylidene]acetamide; mp. 143.3° C.

1. temperaturerefluxed for 5 hours
2. customThe reaction mixture is evaporated
3. stirringthe residue is stirred in water
4. extractionthe product is extracted with trichloromethane
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated
8. customThe residue is crystallized from ethanol
9. filtrationThe product is filtered off
10. customdried