HCID 12568864, compound → HCID 12568866, compound

HRID 2050328Notes

Reaction equation

HRID 2050328 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:8]=[C:9]3[N:17]4[CH2:18][CH2:19][CH2:20][CH2:21][CH:16]4[CH2:15][O:14][C:10]3=[N:11][C:12]=2[CH:13]=1)([O-])=O.[H][H]>[Pd].O1CCOCC1>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[N:8]=[C:9]3[N:17]4[CH2:18][CH2:19][CH2:20][CH2:21][CH:16]4[CH2:15][O:14][C:10]3=[N:11][C:12]=2[CH:13]=1

Participants

5

Reactant 2

HCID 12568864HCID 12568864, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12568866HCID 12568866, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 5.72 g. of 1,2,3,4,4a,5-hexahydro-9-nitropyrido[1',2':4,5][1,4]oxazino[2,3-b]quinoxaline, 200 ml. of dioxane and 1.5 g. of palladium on carbon catalyst is shaken in a Parr hydrogenator under 45 lb. of hydrogen pressure until reduction is complete. The mixture is filtered and the filtrate concentrated to a residue. The residue is recrystallized from ethanol to give the desired product, m.p. 229°-232° C.

Workup

  1. additionA mixture of 5.72 g
  2. filtrationThe mixture is filtered
  3. concentrationthe filtrate concentrated to a residue
  4. customThe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-c3a1f1ced70b4deb98e559eb262c702f
Source dataset
uspto-grants-1980_04
Patent number
US04200748

Reaction notes

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