Benzoyl chloride → HCID 20342555, compound

HRID 2050331Notes

Reaction equation

HRID 2050331 reaction equation
[NH2:1][C:2]1[C:3]2[N:4]=[C:5]3[N:15]4[CH2:16][CH2:17][CH2:18][CH2:19][CH:14]4[CH2:13][O:12][C:6]3=[N:7][C:8]=2[CH:9]=[CH:10][CH:11]=1.[OH-].[Na+].[C:22](Cl)(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(Cl)Cl>[CH2:16]1[N:15]2[C:5]3[C:6]([O:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17]1)=[N:7][C:8]1[CH:9]=[CH:10][CH:11]=[C:2]([NH:1][C:22](=[O:29])[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:3]=1[N:4]=3

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 14798Sodium HydroxideHCID 12568867HCID 12568867, compound

Product 1

HCID 20342555HCID 20342555, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 5.1 g. of 11-amino-1,2,3,4,4a,5-hexahydropyrido[1',2':4,5][1,4]oxazino[2,3-b]quinoxaline, 100 ml. of methylene chloride and 20 ml. of 1 N sodium hydroxide is stirred and 2.8 g. of benzoyl chloride is added. The reaction mixture is stirred overnight and the layers are separated. The methylene chloride layer is washed with water and concentrated and N-(1,2,3,4,4a,5-hexahydropyrido[1',2':4,5][1,4]oxazino[2,3-b] quinoxalin-11-yl)benzamide is obtained.

Workup

  1. additionA mixture of 5.1 g
  2. customthe layers are separated
  3. washThe methylene chloride layer is washed with water
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-013604c1d7e34a048213100f1fdef987
Source dataset
uspto-grants-1980_04
Patent number
US04200748

Reaction notes

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