Hydrochloric Acid → HCID 20342630, compound

Participants

Reaction Steps

To a suspension of cyanopinacolone (25.034 g) in anhydrous toluene (50 ml) and anhydrous methanol (8.9 ml) is added gaseous hydrogen chloride (9.9 g) with cooling and stirring at 5° to 10° C., and the whole mixture is allowed to stand at 5° to 10° C. for 25 hours. The reaction mixture is mixed with n-hexane and the precipitated hydrochloride is filtered and washed with ethyl acetate to give methyl 4,4-dimethyl-3-oxopentanimidate hydrochloride (37.746 g) as crystals melting at 104° to 104.5° C. (decomp.). Yield is 97.5%.

Provenance & Evidence