Thiourea → HCID 20342673, compound

HRID 2050344Notes

Reaction equation

HRID 2050344 reaction equation
Cl.[CH3:2][C:3]1[NH:7][CH:6]=[N:5][C:4]=1[CH2:8]Cl.[NH2:10][C:11]([NH2:13])=[S:12]>CC(C)=O>[CH3:2][C:3]1[N:7]=[C:6]([S:12][C:11](=[NH:10])[NH2:13])[NH:5][C:4]=1[CH3:8]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 124562084-(Chloromethyl)-5-methyl-1H-imidazole--hydrogen chloride (1/1)

Product 1

HCID 20342673HCID 20342673, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5-methyl-4-chloromethyl-imidazole hydrochloride (1.70 g, 0.1 mole) and thiourea (0.84 g, 0.11 mole) were reflucted for 6 hours in acetone (200 ml), giving S-(4-methyl-5-methylimidazolyl)-isothiourea. The solvent was evaporated and a saturated aqueous solution of potassium carbonate (50 ml) was added to the residue. After stirring for 30 minutes at 70° C. and evaporating the water, isopropanol (100 ml) was added and hydrogen chloride was passed into the solution to reach the pH of 1. The inorganic salts was filtered off and the filtrate was evaporated to dryness. Recrystallization from isopropanol yielded the desired compound (1.45 g, 86.8%), m.p. 283°-285° C.

Sources & evidence

ORD record
ord-04c7d17981084224afa973be88a9b7c2
Source dataset
uspto-grants-1980_04
Patent number
US04200761

Reaction notes

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