2-(4-Chlorophenylamino)-3-methylbutanoic acid → (2,4-Dioxo-5-methyl-1-n-propyl-3-imidazolidinyl)methyl 2-(4-chlorophenylamino)-3-methylbutanoate

HRID 2050352Notes

Reaction equation

HRID 2050352 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][OH:8])[C:5](=[O:9])[CH:4]([CH3:10])[N:3]1[CH2:11][CH2:12][CH3:13].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([NH:21][CH:22]([CH:26]([CH3:28])[CH3:27])[C:23](O)=[O:24])=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([NH:21][CH:22]([CH:26]([CH3:28])[CH3:27])[C:23]([O:8][CH2:7][N:6]2[C:5](=[O:9])[CH:4]([CH3:10])[N:3]([CH2:11][CH2:12][CH3:13])[C:2]2=[O:1])=[O:24])=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 137960792-(4-Chlorophenylamino)-3-methylbutanoic acidHCID 20342644(2,4-Dioxo-5-methyl-1-n-propyl-3-imidazolidinyl)methanol

Product 1

HCID 20342663(2,4-Dioxo-5-methyl-1-n-propyl-3-imidazolidinyl)methyl 2-(4-chlorophenylamino)-3-methylbutanoate

Procedure

Using the procedure of Example 1, (2,4-dioxo-5-methyl-1-n-propyl-3-imidazolidinyl)methanol is reacted with the acid chloride of 2-(4-chlorophenylamino)-3-methylbutanoic acid to give (2,4-dioxo-5-methyl-1-n-propyl-3-imidazolidinyl)methyl 2-(4-chlorophenylamino)-3-methylbutanoate (A'; R is carbonyl, R' is ethylidene, R1 =R4 =R5 is hydrogen, R2 is p-chlorophenyl, R3 is isopropyl, R6 is n-propyl).

Sources & evidence

ORD record
ord-56eae6cd0f4246cca46a531a56232468
Source dataset
uspto-grants-1980_04
Patent number
US04200758

Reaction notes

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