2-(Bis(methylsulfanyl)methylidene)propanedinitrile → HCID 178503874, compound

HRID 2050356Notes

Reaction equation

HRID 2050356 reaction equation
CS[C:3](=[C:6]([C:9]#[N:10])[C:7]#[N:8])[S:4][CH3:5].[CH3:11][C:12]1[N:13]=[CH:14][NH:15][C:16]=1[CH2:17][S:18][CH2:19][CH2:20][NH2:21]>C(O)C>[C:9]([C:6]([C:7]#[N:8])=[C:3]([S:4][CH3:5])[NH:21][CH2:20][CH2:19][S:18][CH2:17][C:16]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:11])#[N:10]

Participants

4

Reactant 2

HCID 992292-(Bis(methylsulfanyl)methylidene)propanedinitrileHCID 178433288HCID 178433288, compound

Product 1

HCID 178503874HCID 178503874, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Bis(methylthio)methylenemalononitrile [prepared according to the procedure described in Chem. Ber., 95, 2861 (1962)] (9.94 g, 58.4 mmole) was added with stirring to a solution of 2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamine (10.0 g, 58.4 mmole) in 100 ml of absolute ethanol. After stirring at room temperature for 90 minutes, the solvent was removed by evaporation under reduced pressure, and the residue placed on silica gel and chromatographed to yield the title compound (15.65 g).

Workup

  1. addition, 95, 2861 (1962)] (9.94 g, 58.4 mmole) was added
  2. customthe solvent was removed by evaporation under reduced pressure
  3. customchromatographed

Sources & evidence

ORD record
ord-1594c8fa72454a999878ef4f8260bf29
Source dataset
uspto-grants-1980_04
Patent number
US04200760

Reaction notes

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