Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Diethyl bromomalonate | HCID 69637 | — |
| Catalyst | Tetrabutylammonium Bromide | HCID 74236 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 53814688 | HCID 53814688 | — |
Reaction Steps
To a solution of diethyl 2-bromomalonate (0.15 m) and indole (0.1 m) in 100 ml of benzene is added a solution of sodium hydroxide (0.1 m) in water. To this mixture is added tetra-n-butylammonium bromide (0.5 mmole). This mixture is stirred at about 25° C. for 16 hours. The phases are separated, the organic phase is dried and evaporated to give diethyl (1H-indol-1-yl)malonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04200747 |
|---|
| Source dataset | uspto-grants-1980_04 |
|---|
| ORD ID | ord-7b0858a9080a4c5385f299c0c9d81532 |
|---|
| Source note | uspto-grants-1980_04 |
|---|
