反应详情

65.0 g of 2-chloro-4-fluorobenzyl chloride in 90 ml of toluene and 28.8 g of isobutyraldehyde are added dropwise, simultaneously but separately, with thorough mixing at 80° C. in the course of 30 minutes to a mixture of 1.9 g of tetrabutylammonium iodide, 155 g of 30% strength sodium hydroxide solution and 115 ml of toluene, and stirring is continued for 3 hours at 80° C. The organic phase is separated off, washed with three times 50 ml of water, dried, and concentrated (58.5 g) by short-path distillation (bp.=70°-90° C./0.3). Distillation gives 45.1 g of (2-chloro-4-fluorophenyl)-pivalaldehyde (bp.: 53°-55° C./0.1).

1. customThe organic phase is separated off
2. washwashed with three times 50 ml of water
3. customdried
4. concentrationconcentrated (58.5 g)
5. distillationby short-path distillation (bp.=70°-90° C./0.3)
6. distillationDistillation