Potassium Carbonate → HCID 18645076, compound

Participants

Reaction Steps

A mixture of 0.66 g of 9-decen-1-yl-p-tosylate, 0.5 g of (S)-4-(5-[5-methylheptyl]-2-pyrimidinyl)phenol and 0.97 g of potassium carbonate and 50 ml of absolute butanone was heated under reflux overnight. The cooled reaction mixture was subsequently poured into ice-water and extracted three times with 50 ml of diethyl ether each time. The organic phases were washed with 500 ml of water, dried over magnesium sulphate and concentrated. Chromatography of the residue on silica gel with toluene and subsequent bulb-tube distillation gave 0.9 g of (S)-5-(5-methylheptyl)-2-(4-[9 -decenyloxy]phenyl)pyrimidine; m.p. (C-SC *) 19° C., phase transition (SC *-Ch) 32.5° C., cl.p. (Ch-I) 43° C.

Provenance & Evidence