Trifluoroacetic acid → HCID 20058295, compound

Participants

Reaction Steps

To a stirred suspension of this pyridinium chloride (1 mmol) in dichloromethane (5 ml) at 0° C. was added sufficient trifluoroacetic acid to give a clear solution. A solution of m-chloroperoxybenzoic acid (1 mmol) in dichloromethane (2 ml) was added over about 1 minute and the mixture was allowed to warm to room temperature. After 30 minutes, further m-chloroperoxybenzoic acid (1 mmol) in dichloromethane (2 ml) was added. After a further 15 minutes the solvent was removed by evaporation under reduced pressure and the residue was triturated with ethyl acetate to give 1-(5-methoxypyran-4-on-2-yl)4-methylsulphinylpyridinium chloride as a crude gum (which was used in this form for the reaction of Example 32); (DMSO-d6) 3.00(s,3H); 3.65(s,3H); 6.0(s,2H); 6.70(s,1H); 8.15(s,1H); 8.55(d,2H); 9.42(d,2H).

Provenance & Evidence