4-(Methylthio)pyrimidine → HCID 178503292, compound

HRID 2050492Notes

Reaction equation

HRID 2050492 reaction equation
[Cl:1][CH2:2][C:3]1[CH:8]=[C:7]([OH:9])[C:6]([OH:10])=[CH:5][N:4]=1.[CH3:11][S:12][C:13]1[CH:18]=[CH:17][N:16]=[CH:15][N:14]=1>>[ClH:1].[Cl-:1].[OH:9][C:7]1[C:6]([OH:10])=[CH:5][N:4]=[C:3]([CH2:2][N+:16]2[CH:17]=[CH:18][C:13]([S:12][CH3:11])=[N:14][CH:15]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 53247714-(Methylthio)pyrimidineHCID 178516768HCID 178516768, compound

Product 1

HCID 178503292HCID 178503292, compound

Procedure

2-Chloromethyl-4,5-dihydroxypyridine (1.5 mmol) and 4-methylthiopyrimidine (3 mmol) were heated at 100° C., under argon, for 30 minutes. The mixture was subsequently triturated with methanol at 0° C., filtered, washed and dried to give 1-(4,5-dihydroxypyridin-2-ylmethyl)-4-methylthiopyrimidinium chloride hydrochloride; (DMSO-d6) 2.75(s,3H); 5.90(s,2H); 7.45(s,1H); 8.15(s,1H); 8.17(q,1H); 9.05(q,1H); 9.75(s,1H).

Workup

  1. customThe mixture was subsequently triturated with methanol at 0° C.
  2. filtrationfiltered
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-458f6c0bca9e45ae96bc718c7a105af3
Source dataset
uspto-grants-1991_05
Patent number
US05013730

Reaction notes

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