HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tacrine → HCID 15728813, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tacrine | HCID 1935 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 4-Cyanobenzaldehyde | HCID 66042 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 15728813 | HCID 15728813 | 45.8% |
Reaction Steps
1,2,3,4-Tetrahydro-9-acridinamine (3.2 g) was refluxed in 300 ml of toluene containing morpholine (2.8 g) and 4-cyanobenzaldehyde (2.60 g). After twenty-four (24) hours the reaction mixture was concentrated and purified by flash chromatography. Fractions containing the product were concentrated and recrytallized from CH2Cl2 /pentane to give 2.30 g of product, m.p. 204°-205° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05013741 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-c6909b4d85584654a562f4dd1d9fbe1d |
| Source note | uspto-grants-1991_05 |