Sodium cyanoborohydride → HCID 135621395, compound

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Reaction Steps

A 3.21 g portion of 7-(2,5-dichlorophenyl)-2methylpyrazolo(1,5-a)pyrimidine-3-carboxamide (Example 2) is suspended in 150 ml of glacial acetic acid and stirred under nitrogen at room temperature. Then 1.5 g of sodium cyanoborohydride is added in portions and stirring is continued for 3 hours. The reaction mixture is evaporated to dryness in vacuo and when water is added to the residue a white precipitate forms. This solid is collected and dissolved in dichloromethane, and this solution is washed with an aqueous saturated solution of sodium bicarbonate. Then the organic phase is dried over anhydrous sodium sulfate and filtered. The filtrate is evaporated in vacuo and gives 2.95 g of the product of this example as a white solid, mp 93-96° C.

Provenance & Evidence