Methanol → Hydrogen Bromide

Participants

Reaction Steps

The product of step (b) (3.25 g) was dissolved in dry dichloromethane (10 ml) and cooled to -78°. Boron tribromide (3.5 ml) was added, and the solution stirred at -78° for 3 hours followed by 2 hours at room temperature. Methanol (about 25 ml) was added, and the mixture reduced to dryness. The resulting white solid was crystallised from dry methanol to give the title compound as the dihydrobromide salt, 2 HBr, m.p 210°-4° (dec).

Provenance & Evidence