Methanol → HCID 20058481, compound

Participants

Reaction Steps

A solution of N-(2-hydroxy-2-phenylethyl)-N'-[2-(3,4-bis(phenylmethoxy)phenyl)ethyl]hexane-1,6-diamide prepared in an analogous manner to that described in Example 12(a) above (3.48 g) in dry tetrahydrofuran (100 ml) was stirred under a nitrogen atmosphere whilst diborane in tetrahydrofuran (30 ml of 1M solution) was added and then the solution heated to reflux for 6 hours. Methanol (100 ml) was added to the cooled solution and the mixture evaporated to dryness. The residue was dissolved in methanolic HCl (100 ml) and heated to reflux for 18 hours. The solution was evaporated to dryness and the residue recrystallised from ethanol to give the title compound, as the dihydrochloride salt, colorless prisms (1.3 g) mp 188°-9°.

Provenance & Evidence