Methanol → HCID 20058528, compound

Participants

Reaction Steps

The dihydrochloride from step (c) (2.2 g) in dry dichloromethane (100 ml) was treated with triethylamine (1.3 ml, 0.94 g) and stirred under nitrogen for 15 minutes. The resulting suspension was cooled to -70°, boron tribromide (2.2 ml, 5.85 g) added and the mixture allowed to warm to ambient temperature with stirring over 18 hours. Methanol (10 ml) was added, the resulting solution evaporated to dryness and the solid residue recrystallised from 2-propanol giving the title compound (2.2 g), as the dihydrobromide salt, colorless needles mp 137°-139°.

Provenance & Evidence