HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S,3S)-2-hydroxy-3-(4-methoxyphenyl)-3-(2-acetylaminophenylthio)propionic acid → (S-(R*,R*))-3-((o-Aminophenyl)thio)-3-(p-methoxyphenyl)lactic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S,3S)-2-hydroxy-3-(4-methoxyphenyl)-3-(2-acetylaminophenylthio)propionic acid | HCID 57087568 | — |
| Solvent | Water | HCID 962 | — |
| Product | (S-(R*,R*))-3-((o-Aminophenyl)thio)-3-(p-methoxyphenyl)lactic acid | HCID 6451869 | — |
Reaction Steps
A process for the preparation of 2S-cis-hydroxy-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4-(5H)-one, in which (2S,3S)-2-hydroxy-3-(4-methoxyphenyl)-3-(2-acetylaminophenylthio)propionic acid (I) is subjected to prolonged ebollition with 1 to 5 moles of mineral acid which is diluted with water in 1:25 to 1:50 ratios.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05013834 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-16c6e7f173464a91b4cfba03421ae737 |
| Source note | uspto-grants-1991_05 |