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HRID2050615

反应详情

EQUATION

反应方程式

HRID 2050615 的结构方程式

REACTANTS

反应物

2
结构：C[C@@H](OS(C)(=O)=O)C(=O)O
HCID12761548

未命名化合物

结构：CN1C[C@@H](C(=O)OC(C)(C)C)NC1=O
HCID13053976

tert-Butyl (4S)-1-methyl-2-oxoimidazolidine-4-carboxylate

C9H16N2O3

PRODUCTS

生成物

1
结构：C[C@@H](OS(C)(=O)=O)C(=O)N1C(=O)N(C)C[C@H]1C(=O)OC(C)(C)C
HCID14801858

未命名化合物

收率 75.8%

PROCEDURE

实验过程

D-lactic acid O-mesylate, namely (2R)-2-(methanesulfonyloxy)propionic acid (2.5 g) and t-butyl (4S)-1-methyl-2-oxoimidazolidine-4-carboxylate (3.42 g) were treated similarly as in Example 1 - (1), and the crude product was purified by silica gel chromatography (chloroform:ethyl acetate=1:2) and crystallized from n-hexane to give t-butyl (4S)-1-methyl-3-[(2R)-2-(methanesulfonyloxy)-propionyl]-2-oxoimidazolidine-4carboxylate (3.95 g). Yield: 75.8%., m.p.: 97°-100° C.

WORKUP

后处理

  1. customthe crude product was purified by silica gel chromatography (chloroform:ethyl acetate=1:2)
  2. customcrystallized from n-hexane