HuagongsheHuagongshe Chemistry Print Report · For research reference only
t-Butyl (4S)-1-methyl-3-[(2R)-2-(p-toluenesulfonyloxy)propionyl]-2-oxoimidazolidine-4-carboxylate → HCID 13477732, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | t-Butyl (4S)-1-methyl-3-[(2R)-2-(p-toluenesulfonyloxy)propionyl]-2-oxoimidazolidine-4-carboxylate | HCID 14801853 | — |
| Reactant | (S)-Benzyl 2-amino-4-phenylbutanoate | HCID 15630398 | — |
| Product | HCID 13477732 | HCID 13477732 | 82.3% |
Reaction Steps
t-Butyl (4S)-1-methyl-3-[(2R)-2-(p-toluenesulfonyloxy)propionyl]-2-oxoimidazolidine-4-carboxylate (1 g) obtained in Example 1 - (1) and benzyl (2S)-2-amino-4-phenylbutyrate (1.55 g) were treated similarly as in Example 1 - (2) to give t-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-3-phenyl-propyl)amino]propionyl}-2-oxoimidazolidine-4-carboxylate (1.01 g) as colorless syrup. Yield: 82.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05013845 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-c8effcb744504bdd94a6cd1e516d9b20 |
| Source note | uspto-grants-1991_05 |