rel-(2R,6S)-2,6-dimethylpiperazine → HCID 14880254, compound

HRID 2050632Notes

Reaction equation

HRID 2050632 reaction equation
[NH2:1][C:2]1[C:11]([F:12])=[C:10](F)[CH:9]=[C:8]2[C:3]=1[C:4](=[O:22])[C:5]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:6][N:7]2[CH:14]1[CH2:16][CH2:15]1.[CH3:23][C@H:24]1[NH:29][C@@H:28]([CH3:30])[CH2:27][NH:26][CH2:25]1>>[NH2:1][C:2]1[C:11]([F:12])=[C:10]([N:26]2[CH2:25][C@H:24]([CH3:23])[NH:29][C@H:28]([CH3:30])[CH2:27]2)[CH:9]=[C:8]2[C:3]=1[C:4](=[O:22])[C:5]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:6][N:7]2[CH:14]1[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 14880247HCID 14880247, compound

Product 1

HCID 14880254HCID 14880254, compound

Procedure

Ethyl 5-amino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate and cis-3,5-dimethylpiperazine were reacted in the same way as in Example 4 to give ethyl 5-amino-1-cyclopropyl-6-fluoro-7-(cis-3,5-dimethyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate. It was recrystallized from ethyl acetate. m.p. 194°-196° C.

Sources & evidence

ORD record
ord-73e7f85079c640829d71e3a6ca096d58
Source dataset
uspto-grants-1991_05
Patent number
US05013841

Reaction notes

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