反应详情

A mixture of 5-benzylamino-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 1-acetyl-2-methylpiperazine and pyridine was heated under reflux. The reaction mixture was concentrated under reduced pressure, and water was added to the residue. The mixture was extracted with chloroform. The extract was dried and chloroform was evaporated. Ethanol was added to the residue, and the crystals were collected by filtration to give 7-(4-acetyl-3-methyl-1-piperazinyl)-5-benzylamino-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid. It was recrystallized from ethanol/diisopropyl ether. m.p. 235°-236° C.

1. temperaturewas heated
2. temperatureunder reflux
3. concentrationThe reaction mixture was concentrated under reduced pressure, and water
4. additionwas added to the residue
5. extractionThe mixture was extracted with chloroform
6. customThe extract was dried
7. customchloroform was evaporated
8. additionEthanol was added to the residue
9. filtrationthe crystals were collected by filtration