HCID 20058703, compound → HCID 53829528, compound

Participants

Reaction Steps

A mixture of methylmagnesium chloride (a 3 M solution in tetrahydrofuran; 0.68 ml, 2.04 mmol) and 4-[1-(2-oxopropyl)tridecyl]-2-tert-butyldimethylsilylfuran (Compound 31, 429 mg, 1.02 mmol) in tetrahydrofuran (3 ml) was stirred at 0° at room temperature for 6 hours. The mixture was quenched with saturated ammonium chloride and extracted with ether. Evaporation of the dried (magnesium sulfate) extracts gave an oil, which was chromatographed on a silica column using 5% ethyl acetate/hexane to give the title alcohol.

Provenance & Evidence