HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → HCID 13849017, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Benzyl L-prolinate | HCID 736155 | — |
| Reactant | HCID 13848990 | HCID 13848990 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 13849017 | HCID 13849017 | — |
Reaction Steps
A solution of 1-[[[(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-4-phenylbutyl]methylamino]carbonyl]-L-proline, phenylmethyl ester (7.12 g., 13.6 mmole) is stirred in a saturated solution of hydrochloric acid/ethyl acetate for one hour. The resulting precipitate is collected and washed with ethyl acetate to give 5.63 g. of 1-[[(S)-3-amino-2-oxo-4-phenylbutyl]methylamino]carbonyl]-L-proline, phenylmethyl ester; m.p. 174°-175°; [α]D25 =+16.20°. TLC (silica gel; chloroform:methanol:acetic acid, 4:1:1) Rf =0.60.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05013861 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-0f3192a8ad1a47a8b5f86c82e9f50ae2 |
| Source note | uspto-grants-1991_05 |