関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cyclohexanol | HCID 7966 | — |
| 反応物 | Sodium chloroacetate | HCID 23665759 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Cyclohexoxyacetic acid | HCID 191994 | 83.1% |
反応手順
A solution of cyclohexanol (1.75 g, 17.5 mmol) in THF was added, and the mixture was warmed to 25° C. for 1 hour. The THF was removed by distillation under vacuum, and a solution of sodium chloroacetate (2.5 g, 22 mmol) in DMSO (50 ml) was added. The reaction mixture was treated as in Example 3 and 2.3 g of product (83% yield) was obtained as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05013864 |
|---|
| 出典データセット | uspto-grants-1991_05 |
|---|
| ORD ID | ord-99afaf4f76f64cd1a8deeac02b9f6403 |
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| 出典メモ | uspto-grants-1991_05 |
|---|
