HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopropyl(phenyl)phosphinic acid → 3-Aminopropyl(cyclohexyl)phosphinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopropyl(phenyl)phosphinic acid | HCID 10104206 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Aminopropyl(cyclohexyl)phosphinic acid | HCID 9920701 | 5,311.6% |
Reaction Steps
A mixture of 1.5 g of 3-aminopropyl(phenyl)phosphinic acid in 10 ml of water and 7.9 ml of 1N hydrochloric acid is treated with hydrogen at 25° in the presence of 0.2 g of Nishimura-catalyst (Rh/PtO2). After 1.2 hours hydrogen up-take stops. The reaction mixture is filtered and the filtrate evaporated to dryness. The residue is recrystallized from methanol/propylenoxide to give 1.2 g of 3-aminopropyl(cyclohexyl)phosphinic acid x 0,4 mol hydrochloric acid as a white solid, m.p. 202-203°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05013863 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-ae2f5ae6bc124127b1c71c06525ba10d |
| Source note | uspto-grants-1991_05 |