Phthalic Anhydride → Phthalic Acid

Participants

Reaction Steps

Phthalamic acids have been prepared by addition of a solution of secondary amine in isopropanol at 78° C. to a phthalic anhydride/isopropanol slurry at 78° C. in a one to one phthalic anhydride/amine molar ratio with subsequent vacuum stripping of the solvent. This method utilizes isopropanol as the solvent for the reaction. Isopropanol, a secondary amine, reacts with phthalic anhydride to yield isopropyl mono ester of phthalic acid. At 78° C., as much as 40% of the product may be this ester.

Provenance & Evidence