Sodium borohydride → HCID 67604681, compound

Participants

Reaction Conditions

Reaction Steps

To a cold solution of 1-(3-fluoro-4-pyridinylmethylamino)-1H-pyrrol-2-carboxaldehyde (5.0 g) in 100 ml of ethanol, was added NaBH4 (2.0 g). After stirring at 5° C. for one hour, and then at ambient temperature for an additional hour, the mixture was concentrated to an oil, which was stirred with 100 ml of water for five minutes and extracted with ethyl acetate. The organic layer was washed with water and dried (saturated NaCl, anhydrous MgSO4).

Provenance & Evidence