Hydrazine hydrate (1:1) → HCID 19834150, compound

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Reaction Steps

A solution of 11.0 g (18.97 mmol) of N-ethyl 4-(2-benzyloxyphenyl)-1,4-dihydro-2,6-dimethyl-3-(2-phthalimido-ethoxycarbonyl)-pyridine-5-carboxamide (Example 28) and 95.0 mmol of hydrazine hydrate are heated under reflux in 100 ml of ethanol for 2 h. The solution is then cooled and the residue is filtered. The latter is subsequently washed with methylene chloride and the filtrate is concentrated in vacuo. The concentrated residue is then washed once with a 2 N solution of potassium hydroxide and then 3 times with water. The product is purified on a silica gel column using methylene chloride/methanol mixtures.

Provenance & Evidence