HuagongsheHuagongshe Chemistry Print Report · For research reference only
Perchloric Acid → 1-azabicyclo-[2,2,2]-octan-3-carboxaldehyde O-ethyloxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Perchloric Acid | HCID 24247 | — |
| Reactant | O-ethylhydroxylamine hydrochloride | HCID 76850 | — |
| Reactant | 3-Methoxy methylidene quinuclidine | HCID 53772600 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-azabicyclo-[2,2,2]-octan-3-carboxaldehyde O-ethyloxime | HCID 53800597 | — |
Reaction Steps
4.8 cm3 of a 70% aqueous solution of perchloric acid is added at ambient temperature to 2 g of 3-methoxy methylidene quinuclidine in solution in 20 cm3 of chloroform. After agitating for one hour, 1.4 g of O-ethylhydroxylamine hydrochloride in 2.5 cm3 of methanol and 2.5 cm3 of water are added, and the reaction medium is maintained in this way for one night. After concentrating, alkalizing with sodium hydroxide, extracting with ethyl acetate, and distilling at 135° C. under 0.05 mbar, 2.05 g of expected product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05015655 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-97a38e115fbb4006bfa2104bfba3e97b |
| Source note | uspto-grants-1991_05 |