Hydrochloric Acid → HCID 178509358, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,1-biscyanocyclopentane (58 g), sodium azide (29.9 g, 460 mmoles) and ammonium chloride (28.5 g, 531 mmoles) in DMF (500 mL) was stirred and heated at 130° C. for 90 minutes. The cooled mixture was poured into 0.5 M HCl (1 liter) and extracted with ether (2×500 mL). The combined ether extracts were washed with water (2×200 mL), brine (100 mL), and dried (MgSO4). Filtration and concentration provided a solid which was recrystallized from isopropylether-hexane (16.8 g). Melting point 92°-94° C.

Provenance & Evidence