Diazomethane → HCID 15080563, compound

HRID 2050910Notes

Reaction equation

HRID 2050910 reaction equation
[N+](=[CH2:3])=[N-].[NH2:4][C@H:5]([C:18]([OH:20])=[O:19])[CH2:6][C:7]#[C:8][CH2:9][NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>CCOCC.C(O)C>[NH2:4][C@H:5]([C:18]([O:20][CH3:3])=[O:19])[CH2:6][C:7]#[C:8][CH2:9][NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:15])[CH3:16])=[O:12]

Participants

5

Reactant 2

HCID 9550DiazomethaneHCID 10633910HCID 10633910, compound

Product 1

HCID 15080563HCID 15080563, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

Titrate a solution of diazomethane in ether into a solution of 1-amino-1-(S)-carboxy-5-(t-butoxycarbonyl amino)-3-pentyne (4 g) in ethanol (200 ml) until a yellow color remains. Evaporate the solvent to obtain 1-amino-1-(s)-methoxycarbonyl-5-(t-butoxycarbonylamino)-3pentyne.

Workup

  1. customEvaporate the solvent

Sources & evidence

ORD record
ord-d755c3bd8e8f43b5a0b582243d42b0c9
Source dataset
uspto-grants-1991_05
Patent number
US05015641

Reaction notes

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