Hydrochloric Acid → HCID 86744774, compound

Participants

Reaction Steps

17.6 g of powdered sodium hydroxide are added in portions to a mixture of 22 g of 2-thienylglyoxylic acid N-hydroxycarbonylmethyl-amide (prepared from aminoacetic acid and ethyl 2-thienylglyoxylate, melting point 168°-170° C.), 15 ml of water, 50 ml of methanol and 9.5 g of hydroxylamine hydrochloride. The temperature is maintained at 40°-50° C. by cooling and the mixture is then stirred at room temperature for 2 h. It is acidified with concentrated hydrochloric acid and then the volatile fractions are stripped off in a rotary evaporator. The residue is boiled with 300 ml of ethanol and filtered with active charcoal, and the filtrate is concentrated in vacuo. The residue is stirred with diethyl ether and filtered off with suction.

Provenance & Evidence