Ethanol → 2-Tricyclo(3.3.1.13,7)dec-1-yl-1-naphthalenol

HRID 2051089노트

반응식

HRID 2051089 반응식
C(O[C:5]12[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([CH2:8]3)[CH2:6]1)[CH2:12]2)(=O)C.S(=O)(=O)(O)O.[C:20]1([OH:30])[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][CH:21]=1.C(O)C>C1CCCCC1>[C:5]12([C:21]3[CH:22]=[CH:23][C:24]4[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=4)[C:20]=3[OH:30])[CH2:14][CH:9]3[CH2:10][CH:11]([CH2:13][CH:7]([CH2:8]3)[CH2:6]1)[CH2:12]2

참가 물질

6

반응물 4

HCID 702EthanolHCID 1118Sulfuric AcidHCID 70051-NaphtholHCID 5199731-Adamantyl acetate

생성물 1

HCID 198345082-Tricyclo(3.3.1.13,7)dec-1-yl-1-naphthalenol수율 20.7%

시약·촉매·용매 1

HCID 8078Cyclohexane용매2회

실험 절차

A three-necked 100 ml flask is charged with 2.7 g of 1-acetoxyadamantane and 5 ml of cyclohexane in a nitrogen atmosphere. After complete dissolution, there are introduced 1.4 g of concentrated sulfuric acid. In a single portion there is added a suspension of 2 g of 1-naphthol in 15 ml of cyclohexane and one agitates for 45 minutes. 20 ml of ethanol are added and the mixture is filtered. One washes the residue with ethanol and with water and dries on the filter. After recrystallization with cyclohexane, one obtained 0.8 g of the desired product melting at 209.2°-209.6° C.

후처리

  1. dissolutionAfter complete dissolution, there
  2. additionIn a single portion there is added
  3. filtrationthe mixture is filtered
  4. customAfter recrystallization with cyclohexane, one

출처 및 근거

ORD 기록
ord-62f4e1c95f6c48939dd75d78f8726d6f
출처 데이터셋
uspto-grants-1991_05
특허 번호
US05015758

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