Ethyl 3-amino-4,4,4-trifluorocrotonate → HCID 19832705, compound

HRID 2051092Notes

Reaction equation

HRID 2051092 reaction equation
[F:1][C:2]([F:12])([F:11])/[C:3](/[NH2:10])=[CH:4]/[C:5]([O:7]CC)=O.[Cl:13][C:14]1[C:25]([C:26](=[O:31])[NH:27][CH:28]([CH3:30])[CH3:29])=[CH:24][C:17]([NH:18][C:19](=O)[O:20]CC)=[C:16]([F:32])[CH:15]=1>>[CH:28]([NH:27][C:26](=[O:31])[C:25]1[CH:24]=[C:17]([N:18]2[C:5](=[O:7])[CH:4]=[C:3]([C:2]([F:1])([F:11])[F:12])[NH:10][C:19]2=[O:20])[C:16]([F:32])=[CH:15][C:14]=1[Cl:13])([CH3:30])[CH3:29]

Participants

3

Reactant 2

HCID 5702529Ethyl 3-amino-4,4,4-trifluorocrotonateHCID 19832678HCID 19832678, compound

Product 1

HCID 19832705HCID 19832705, compound

Procedure

Analogously to the procedure described in Example 1, starting from ethyl 4,4,4-trifluoro-3-aminocrotonate and ethyl 4-chloro-2-fluoro-5-(N-isopropylcarbamoyl)-carbanilate there is obtained N-isopropyl-2-chloro-5-[3,6-dihydro-2,6-dioxo-4-trifluoromethyl-1(2H)-pyrimidinyl]-4-fluorobenzamide, m.p. 234°-239° C.

Sources & evidence

ORD record
ord-10485c3f0ae2493bb8f0190b1b257d68
Source dataset
uspto-grants-1991_05
Patent number
US05017211

Reaction notes

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