Ethyl chloroformate → HCID 19832678, compound

HRID 2051098Notes

Reaction equation

[CH:1]([NH:4][C:5](=[O:15])[C:6]1[CH:11]=[C:10]([NH2:12])[C:9]([F:13])=[CH:8][C:7]=1[Cl:14])([CH3:3])[CH3:2].Cl[C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[Cl:14][C:7]1[C:6]([C:5](=[O:15])[NH:4][CH:1]([CH3:3])[CH3:2])=[CH:11][C:10]([NH:12][C:17](=[O:18])[O:19][CH2:20][CH3:21])=[C:9]([F:13])[CH:8]=1

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 19832682HCID 19832682, compound

Product 1

HCID 19832678HCID 19832678, compound

Procedure

Analogously to the procedure described in Example 65, starting from N-isopropyl-5-amino-2-chloro-4-fluorobenzamide and ethyl chloroformate there is obtained ethyl 4-chloro-2-fluoro-5-(N-isopropylcarbamoyl)-carbanilate, m.p. 127°-130° C., used as the starting material in Example 2.

Sources & evidence

ORD record: ord-1c99a9ba177a435891746aa168c86c9f
Source dataset: uspto-grants-1991_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05017211

Reaction notes

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