HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2051112Generated: November 1, 2026
Sodium Hydroxide → 6-Bromoimidazo[2,1-b][1,3]thiazole
https://huagongshe.com/reaction/2051112
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Phosphorus oxybromide | HCID 24613 | — |
| Reactant | HCID 67866643 | HCID 67866643 | — |
| Product | 6-Bromoimidazo[2,1-b][1,3]thiazole | HCID 329949 | — |
Reaction Steps
A mixture of 10.0 g of 2-imino-4-thiazolin-3-yl-acetic acid hydrobromide and 30.0 g of phosphorus oxybromide is heated for 2 hours at 140° C. After cooling, the reaction mixture is poured into ice water, neutralized with 10% sodium hydroxide solution and filtered to collect the precipitated crystals. The crystals are recrystallized from toluene to afford the title compound of mp. 96°-98° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05017212 |
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| Source dataset | uspto-grants-1991_05 |
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| ORD ID | ord-2369136b2bfa4f46bd4e240109c3e8f1 |
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| Source note | uspto-grants-1991_05 |
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