Sodium Hydroxide → HCID 178526125, compound

Participants

Reaction Steps

To a solution of 3.5 g of ethyl 6-benzylthioimidazo [2,1-b]thiazole-5-carboxylate in 25 ml of ethanol is added sodium hydroxide solution (prepared by dissolving 1.5 g of sodium hydroxide in 7 ml of water) and the mixture is stirred for 30 minutes at 50°-60° C. and then under reflux for 20 minutes. The reaction solution is concentrated, added with 70 ml of water and adjusted to pH 3 by addition of hydrochloric acid. The precipitate is collected by filtration and dried to obtain 3.0 g of the title compound, mp. 147°-150° C. (decomp.).

Provenance & Evidence