反应详情

To a solution of 3.0 g of 2-chloromethylimidazo [1,2-a]pyridine in 50 ml of methanol is added 1.1 g of sodium methoxide, followed by heating under reflux for 3 hours. Methanol is distilled off under reduced pressure and chloroform is added to the residue. The resulting insoluble substance is filtered off, and the filtrate is washed with water and dried over anhydrous sodium sulfate. After distilling chloroform off, 2.9 g of the title compound is obtained as crystals.

1. temperatureby heating
2. temperatureunder reflux for 3 hours
3. distillationMethanol is distilled off under reduced pressure and chloroform
4. additionis added to the residue
5. filtrationThe resulting insoluble substance is filtered off
6. washthe filtrate is washed with water
7. dry with materialdried over anhydrous sodium sulfate
8. distillationAfter distilling chloroform off, 2.9 g of the title compound
9. customis obtained as crystals