2-Chloromethyl-imidazo(1,2-A)pyridine → HCID 3435423, compound

HRID 2051115Notes

Reaction equation

HRID 2051115 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[CH:11]=1.[CH3:12][O-:13].[Na+]>CO>[CH3:12][O:13][CH2:2][C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[CH:11]=1

Participants

4

Reactant 2

HCID 9576142-Chloromethyl-imidazo(1,2-A)pyridineHCID 10942334Sodium Methoxide

Product 1

HCID 3435423HCID 3435423, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3.0 g of 2-chloromethylimidazo [1,2-a]pyridine in 50 ml of methanol is added 1.1 g of sodium methoxide, followed by heating under reflux for 3 hours. Methanol is distilled off under reduced pressure and chloroform is added to the residue. The resulting insoluble substance is filtered off, and the filtrate is washed with water and dried over anhydrous sodium sulfate. After distilling chloroform off, 2.9 g of the title compound is obtained as crystals.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 3 hours
  3. distillationMethanol is distilled off under reduced pressure and chloroform
  4. additionis added to the residue
  5. filtrationThe resulting insoluble substance is filtered off
  6. washthe filtrate is washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. distillationAfter distilling chloroform off, 2.9 g of the title compound
  9. customis obtained as crystals

Sources & evidence

ORD record
ord-37b502b3a3104ffaa6e02c894a4c5674
Source dataset
uspto-grants-1991_05
Patent number
US05017212

Reaction notes

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