HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetylacetone → 2,5,7-trimethylpyrazolo[1,5-a]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetylacetone | HCID 31261 | — |
| Reactant | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2,5,7-trimethylpyrazolo[1,5-a]pyrimidine | HCID 3611062 | — |
Reaction Steps
A mixture of 9.7 g of 3-amino-5-methylpyrazole, 13 ml of acetylacetone and 50 ml of isopropanol is heated under reflux for 3 hours. After distilling isopropanol off, the residue is dissolved in dichloromethane, washed with water and dried over anhydrous magnesium sulfate when chloroform is distilled off, 12.7 g of the title compound is obtained as crystals. mp. 70°-73° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05017212 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-cbdd7df021f24864a7fd27b6ce766633 |
| Source note | uspto-grants-1991_05 |