反应详情

A solution of 4.6 g of 2-chloroimidazo[1,2-a]pyridine-3-sulfonylchloride in 60 ml of acetonitrile is added to 60 ml of aqueous ammonia under cooling and stirred for 2 hours at room temperature. The reaction solution is distilled under reduced pressure to remove acetonitrile, and the precipitated crystals are collected by filtration and washed with water to give 3.8 g of the title compound. Upon recrystalization from diluted ethanol, it gives colorless needles mp. 175°-177° C.

1. temperatureunder cooling
2. distillationThe reaction solution is distilled under reduced pressure
3. customto remove acetonitrile
4. filtrationthe precipitated crystals are collected by filtration
5. washwashed with water