Sodium Methoxide → HCID 14422369, compound

HRID 2051132Notes

Reaction equation

HRID 2051132 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([S:12]([NH2:15])(=[O:14])=[O:13])=[C:9]([CH3:11])[N:10]=2)[N:7]=1.[CH3:16][O-:17].[Na+]>CO>[CH3:16][O:17][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([S:12]([NH2:15])(=[O:14])=[O:13])=[C:9]([CH3:11])[N:10]=2)[N:7]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 14422372HCID 14422372, compound

Product 1

HCID 14422369HCID 14422369, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4.9 g of 6-chloro-2-methylimidazo [1,2-b]pyridazine-3-sulfonamide in 50 ml of methanol is added 2.2 g of sodium methylate, followed by refluxing for 4 hours. Methanol is distilled off and the residue after addition of water is neutralized with hydrochloric acid. The precipitated crystals are collected by filtration and dried to give 4.8 g of the title compound. mp. 251° C.

Workup

  1. temperatureby refluxing for 4 hours
  2. distillationMethanol is distilled off
  3. additionthe residue after addition of water
  4. filtrationThe precipitated crystals are collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-971aa49de8e3482e9e354371d2065870
Source dataset
uspto-grants-1991_05
Patent number
US05017212

Reaction notes

Loading…