16,16-Dimethyl-pge2 → HCID 101661362, compound

HRID 2051146Notes

Reaction equation

HRID 2051146 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]([C@H:8]([OH:27])/[CH:9]=[CH:10]/[C@@H:11]1[C@@H:16]([CH2:17]/[CH:18]=[CH:19]\[CH2:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:14](=[O:15])[CH2:13][C@H:12]1[OH:26])([CH3:7])[CH3:6].[CH:28](Cl)(Cl)Cl.C(Cl)(Cl)Cl>>[CH3:1][CH2:2][CH2:3][CH2:4][C:5]([C@@H:8]([OH:27])/[CH:9]=[CH:10]/[C@@H:11]1[C@@H:16]([CH2:17]/[CH:18]=[CH:19]\[CH2:20][CH2:21][CH2:22][C:23]([O:25][CH3:28])=[O:24])[C:14](=[O:15])[CH2:13][C@H:12]1[OH:26])([CH3:7])[CH3:6]

Participants

3

Reactant 2

HCID 528306616,16-Dimethyl-pge2HCID 22660621HCID 22660621, compound

Product 1

HCID 101661362HCID 101661362, compound

Procedure

2 mg 3H labelled 16,16-dimethyl PGE2, methyl ester Ono 802 ex May and Baker is dissolved in 0.67 g ethanol C2H5OH, 0.67 g chloroform CHCl3 is added. A slice of the polymer 1 mm×11 mm×22 mm weighing 0.2678 g is added to the Ono solution in a polythene bag which is then sealed. After 6 hours swelling the bag is cut open and the swollen gel is weighed. Uptake 0.97 g solution i.e. 1.45 mg Ono. The sample is then dried and the in vitro release of Ono into phosphate buffer pH 7.4 at 37° is measured as in Ex. 12. The half life of Ono in this sample is 6.3 hours. The results for 3 different thicknesses of polymer sample are given to the Table.

Workup

  1. customis then sealed
  2. customThe sample is then dried
  3. customat 37°
  4. waitThe half life of Ono in this sample is 6.3 hours
  5. customThe results for 3 different thicknesses of polymer sample

Sources & evidence

ORD record
ord-659928d6ddaa45159d7a9aba2182033a
Source dataset
uspto-grants-1991_05
Patent number
US05017382

Reaction notes

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