HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(2-Hydroxy-6-methoxyphenyl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2',6'-Dihydroxyacetophenone | HCID 69687 | — |
| Reactant | Methyl sulfate(1-) | HCID 4694097 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-(2-Hydroxy-6-methoxyphenyl)ethan-1-one | HCID 69709 | 60% |
Reaction Steps
A mixture of 25 mmoles of 2,6-dihydroxy acetophenone, 26 mmoles of methyl sulphate, 75 mmoles of K2CO3 and 60 ml of acetone are heated to reflux for 12 hours. Then the reaction medium is cooled, the mineral matter is separated by filtration and rinsed with dichloromethane. After evaporation of the organic phase and flash chromatography, the expected product is obtained in a practically quantitave way (mp =55° C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05017572 |
| Source dataset | uspto-grants-1991_05 |
| ORD ID | ord-4a337a01dfcd4ad1b0a00b3eed5e5139 |
| Source note | uspto-grants-1991_05 |