Potassium Carbonate → HCID 14552892, compound

Participants

Reaction Conditions

Reaction Steps

Anhydrous potassium carbonate (2.2 g) is added to a stirred suspension of 2-(4-methylphenyl)-5-trifluoromethyl-4-quinolone (2.4 g) and 4-(2-chloroacetyl)morpholine (1.3 g) in 2-butanone (50 cc). The mixture is heated to reflux for 3 hours and cooled to room temperature (approximately 20° C.). The insoluble matter is removed by filtration and rinsed with 2-butanone. The organic phases are combined and the solvent is removed under reduced pressure. After recrystallation of the residue from acetonitrile, 4-{[2(4-methylphenyl)-5-trifluoromethyl-4-quinolyl]oxyacetyl}morpholine (2.6 g), m.p. 172° C. is isolated.

Provenance & Evidence