Potassium Carbonate → HCID 14552918, compound

Participants

Reaction Conditions

Reaction Steps

anhydrous potassium carbonate (2.28 g) is added to a stirred suspension of 2-(4-methylphenyl)-5-methoxy-4-quinolone (2.19 g) and 4-(2-chloroacetyl)morpholine (1.62 g) in 2-butanone (76 cc). The mixture is heated to reflux for 4 hours 20 minutes and cooled to room temperature (approximately 20° C.) and the solvent is evaporated off under reduced pressure. The residue is taken up with water and ethyl acetate and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated under reduced pressure. The residue obtained is chromatographed on silica gel, using a chloroform/acetone mixture (95:5 by volume). The solid collected is stirred in 40°-60° petroleum ether (50 cc). 4-{[2-(4-Methylphenyl)-5-methoxy-4-quinolyl]oxyacetyl}morpholine (2.3 g), m.p. 132° C., is thereby isolated.

Provenance & Evidence