Potassium Carbonate → HCID 131716893, compound

Participants

Reaction Conditions

Reaction Steps

4-(2-Bromoacetyl)morpholine (7.3 g) in 2 butanone (50 cc) is added to a stirred suspension of a mixture (11.2 g of 5-fluoro-2-(4-methylphenyl)-4-quinolone and 7-fluoro-2-(4-methylphenyl)-4-quinolone and anhydrous potassium carbonate (11.3 g) in 2-butanone (250 cc). The mixture is heated to reflux for 15 hours and cooled to room temperature (approximately 20° C.), the insoluble matter is removed by filtration and the 2-butanone is evaporated off under reduced pressure. The residue is taken up with water (200 cc) and the aqueous phase is extracted with methylene chloride (3×100 cc). The organic phase is separated after settling has taken place, dried and evaporated under reduced pressure. After chromatography of the residue on silica gel by means of cyclohexane/ethyl acetate mixture (70:30 by volume) as eluant, the solid obtained is ground in 40°-60° C. petroleum ether (100 cc). 4-≡[5-fluoro-2-(4-methylphenyl-4-quinolyl]oxyacetyl}morpholine (2.4 g), m.p. 142°-4° C., is thereby obtained.

Provenance & Evidence