HCID 10428804, compound → HCID 14999042, compound

HRID 2051182Notes

Reaction equation

HRID 2051182 reaction equation
C([N:8]1[CH2:14][CH:13]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][N:19]=2)=[O:17])[CH2:12][N:11]([CH3:27])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:27][N:11]1[CH2:12][CH:13]([NH:15][C:16]([C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][N:19]=2)=[O:17])[CH2:14][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 10428804HCID 10428804, compound

Product 1

HCID 14999042HCID 14999042, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

N-(1-Benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide (850 mg) is dissolved in ethanol (40 ml) and hydrogenerated over 10% palladium on carbon (100 mg) at about 50° C. After the calculated amount of the hydrogen is absorbed, the catalyst is filtered off. The filtrate is evaporated under reduced pressure to give the title compound as an oil. The free base thus obtained is converted to the oxalate 3/2 hydrate of the title compound in a usual manner, m.p. 163-166° C. (recrystallzed from ethanol-diethyl ether).

Workup

  1. customAfter the calculated amount of the hydrogen is absorbed
  2. filtrationthe catalyst is filtered off
  3. customThe filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-08e3f8da5f2c425b9805b55c8a48e07d
Source dataset
uspto-grants-1991_05
Patent number
US05017573

Reaction notes

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