HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2051191Generated: October 25, 2026
Tris(hydroxymethyl)nitromethane → 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine
https://huagongshe.com/reaction/2051191
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tris(hydroxymethyl)nitromethane | HCID 31337 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | N~1~-Benzyl-N~2~-methylethane-1,2-diamine | HCID 10920861 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine | HCID 14938638 | — |
Reaction Steps
To a mixture of tris(hydroxymethyl)nitromethane (118.9 g), sodium bicarbonate (40 g) and water (1000 ml), N-benzyl-N'-methylethylenediamine (123 g) is added, and the reaction mixture is heated at about 50° C. for 2 hours. After cooling, the solution is extracted with dichloromethane, and the organic layer is washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The solvent is evaporated under reduced-pressure to give 1-benzyl-6-hydroxymethyl-4-methyl-6-nitrohexahydro-1H-1,4-diazepine as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05017573 |
|---|
| Source dataset | uspto-grants-1991_05 |
|---|
| ORD ID | ord-246326a0c3944d1fb2bc59d4a7c76cad |
|---|
| Source note | uspto-grants-1991_05 |
|---|
